| Short Description : | Rabbit polyclonal DTNA (240-480) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DTNA |
| Gene ID: | 1837 |
| Uniprot ID: | DTNA_HUMAN |
| Immunogen Region: | 240-480 |
| Immunogen Sequence: | PVECSYCHSESMMGFRYRCQ QCHNYQLCQDCFWRGHAGGS HSNQHQMKEYTSWKSPAKKL TNALSKSLSCASSREPLHPM FPDQPEKPLNLAHIVDTWPP RPVTSMNDTLFSHSVPSSGS PFITRSSPPKDSEVEQNKLL ARAAPAFLKGKGIQYSLNVA DRLADEHVLIGLYVNMLRNN PSCMLESSNRLDEEHRLIAR YAARLAAESSSSQPPQQRSA PDISFTIDANKQQRQLIAE |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-480 of human DTNA (NP_001381.2). |
| Tissue Specificity | Highly expressed in brain, skeletal and cardiac muscles, and expressed at lower levels in lung, liver and pancreas. Isoform 2 is not expressed in cardiac muscle. Isoform 7 and isoform 8 are only expressed in muscle. |
| Post Translational Modifications | Phosphorylation of DTN-1 on tyrosine kinase substrate domain present in the C-terminus. |
| Function | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. |
| Protein Name | Dystrobrevin AlphaDtn-AAlpha-DystrobrevinDystrophin-Related Protein 3 |
| Database Links | Reactome: R-HSA-9913351 |
| Cellular Localisation | CytoplasmSynapseCell MembraneIn Peripheral NervesColocalizes With Magee1 In The Schwann Cell Membrane |
| Alternative Antibody Names | Anti-Dystrobrevin Alpha antibodyAnti-Dtn-A antibodyAnti-Alpha-Dystrobrevin antibodyAnti-Dystrophin-Related Protein 3 antibodyAnti-DTNA antibodyAnti-DRP3 antibody |
Information sourced from Uniprot.org
