| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IF/FC |
| Reactivity: |
Human/Mouse/Rat/Dog |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-DSCAM (Internal) is suitable for use in ELISA, Western Blot, Immunofluorescence and Flow Cytometry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-2-3µg/mlIF-Strong expression of the protein seen in the nuclei of MCF7 cells. 10µg/mlFC-Flow cytometric analysis of MCF7 cells. 10ug/mlELISA-antibody detection limit dilution 1:16000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
DSCAM |
| Gene ID: |
1826 |
| Uniprot ID: |
DSCAM_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_001380.2; NP_001258463.1 |
| Specificity: |
This antibody is expected to recognise both reported isoforms (NP_001380.2 and NP_996770.1). |
| Immunogen Sequence: |
DSWDSAQRTKDVSPQ |
| Post Translational Modifications | Phosphorylated at tyrosine residues. Phosphorylation is enhanced by NTN1. |
| Function | Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC. In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38. Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions. |
| Protein Name | Cell Adhesion Molecule DscamChd2Down Syndrome Cell Adhesion Molecule |
| Database Links | Reactome: R-HSA-376172 |
| Cellular Localisation | Isoform Short: SecretedIsoform Long: Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxonDendriteGrowth ConeSynapseLocalized In The SomaCell MembraneAxon And Growth Cone Of Dissociated Commissural Axons |
| Alternative Antibody Names | Anti-Cell Adhesion Molecule Dscam antibodyAnti-Chd2 antibodyAnti-Down Syndrome Cell Adhesion Molecule antibodyAnti-DSCAM antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
