| Tissue Specificity | Ubiquitous. Highly expressed in adult testis, heart, skeletal muscle, pancreas and brain, and in fetal brain, liver and kidney. |
| Post Translational Modifications | Phosphorylation reduces DNA binding, but has no effect on heterodimerization and TBP binding. |
| Function | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. |
| Protein Name | Dr1-Associated CorepressorDr1-Associated Protein 1Negative Cofactor 2-AlphaNc2-Alpha |
| Database Links | Reactome: R-HSA-1181150Reactome: R-HSA-1502540 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dr1-Associated Corepressor antibodyAnti-Dr1-Associated Protein 1 antibodyAnti-Negative Cofactor 2-Alpha antibodyAnti-Nc2-Alpha antibodyAnti-DRAP1 antibody |
Information sourced from Uniprot.org
