| Short Description : | Rabbit polyclonal DRAP1 (50-150) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DRAP1 |
| Gene ID: | 10589 |
| Uniprot ID: | NC2A_HUMAN |
| Immunogen Region: | 50-150 |
| Immunogen Sequence: | LKKACQVTQSRNAKTMTTSH LKQCIELEQQFDFLKDLVAS VPDMQGDGEDNHMDGDKGAR RGRKPGSGGRKNGGMGTKSK DKKLSGTDSEQEDESEDTDT D |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-150 of human DRAP1 (NP_006433.2). |
| Tissue Specificity | Ubiquitous. Highly expressed in adult testis, heart, skeletal muscle, pancreas and brain, and in fetal brain, liver and kidney. |
| Post Translational Modifications | Phosphorylation reduces DNA binding, but has no effect on heterodimerization and TBP binding. |
| Function | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. |
| Protein Name | Dr1-Associated CorepressorDr1-Associated Protein 1Negative Cofactor 2-AlphaNc2-Alpha |
| Database Links | Reactome: R-HSA-1181150Reactome: R-HSA-1502540 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dr1-Associated Corepressor antibodyAnti-Dr1-Associated Protein 1 antibodyAnti-Negative Cofactor 2-Alpha antibodyAnti-Nc2-Alpha antibodyAnti-DRAP1 antibody |
Information sourced from Uniprot.org
