Anti-Phospho-TNFRSF21-Ser562 antibody (STJ196287)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized phosho peptide around human DR6 (Ser562)
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Tumor necrosis factor receptor superfamily member 21-Ser562 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TNFRSF21 |
| Gene ID | 27242 |
| Uniprot ID | TNR21_HUMAN |
| Immunogen | Synthesized phosho peptide around human DR6 (Ser562) |
| Specificity | This antibody detects endogenous levels of Human Mouse Rat DR6 (phospho-Ser562) |
Additional Info
| Post Translational Modifications | Oxidized in response to reactive oxygen species (ROS), leading to endocytosis. |
| Function | Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. Also acts as a regulator of pyroptosis: recruits CASP8 in response to reactive oxygen species (ROS) and subsequent oxidation, leading to activation of GSDMC. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 21Death Receptor 6Cd Antigen Cd358 |
| Database Links | Reactome: R-HSA-1989781 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEndocytosed Following Oxidation In Response To Reactive Oxygen Species (Ros) |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 21 antibodyAnti-Death Receptor 6 antibodyAnti-Cd Antigen Cd358 antibodyAnti-TNFRSF21 antibodyAnti-DR6 antibodyAnti-UNQ437 antibodyAnti-PRO868 antibody |
Information sourced from Uniprot.org