| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DR1 |
| Gene ID: | 1810 |
| Uniprot ID: | NC2B_HUMAN |
| Immunogen Region: | 1-176 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-176 of human DR1 (NP_001929.1). |
| Immunogen Sequence: | MASSSGNDDDLTIPRAAINK MIKETLPNVRVANDARELVV NCCTEFIHLISSEANEICNK SEKKTISPEHVIQALESLGF GSYISEVKEVLQECKTVALK RRKASSRLENLGIPEEELLR QQQELFAKARQQQAELAQQE WLQMQQAAQQAQLAAASASA SNQAGSSQDEEDDDDI |
| Post Translational Modifications | Phosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1. |
| Function | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. |
| Protein Name | Protein Dr1Down-Regulator Of Transcription 1Negative Cofactor 2-BetaNc2-BetaTata-Binding Protein-Associated Phosphoprotein |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-9772755 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Protein Dr1 antibodyAnti-Down-Regulator Of Transcription 1 antibodyAnti-Negative Cofactor 2-Beta antibodyAnti-Nc2-Beta antibodyAnti-Tata-Binding Protein-Associated Phosphoprotein antibodyAnti-DR1 antibody |
Information sourced from Uniprot.org