| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DPH2 (120-330) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DPH2 |
| Gene ID: |
1802 |
| Uniprot ID: |
DPH2_HUMAN |
| Immunogen Region: |
120-330 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 120-330 of human DPH2 (NP_001375.2). |
| Immunogen Sequence: |
VAFVLRQRSVALELCVKAFE AQNPDPKAPVVLLSEPACAH ALEALATLLRPRYLDLLVSS PAFPQPVGSLSPEPMPLERF GRRFPLAPGRRLEEYGAFYV GGSKASPDPDLDPDLSRLLL GWAPGQPFSSCCPDTGKTQD EGARAGRLRARRRYLVERAR DARVVGLLAGTLGVAQHREA LAHLRNLTQAAGKRSYVLAL GRPTPAKLANF |
| Tissue Specificity | Strongly expressed in skeletal muscle. Moderately expressed in heart, small intestine, liver, pancreas, testis and colon. Weakly expressed in brain, placenta, kidney, spleen, thymus, prostate, ovary and lymphocytes. |
| Function | Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit. |
| Protein Name | 2-(3-Amino-3-Carboxypropylhistidine Synthase Subunit 2Diphthamide Biosynthesis Protein 2Diphtheria Toxin Resistance Protein 2S-Adenosyl-L-Methionine -L-Histidine 3-Amino-3-Carboxypropyltransferase 2 |
| Database Links | Reactome: R-HSA-5358493 |
| Alternative Antibody Names | Anti-2-(3-Amino-3-Carboxypropylhistidine Synthase Subunit 2 antibodyAnti-Diphthamide Biosynthesis Protein 2 antibodyAnti-Diphtheria Toxin Resistance Protein 2 antibodyAnti-S-Adenosyl-L-Methionine -L-Histidine 3-Amino-3-Carboxypropyltransferase 2 antibodyAnti-DPH2 antibodyAnti-DPH2L2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
