| Tissue Specificity | Strongly expressed in skeletal muscle. Moderately expressed in heart, small intestine, liver, pancreas, testis and colon. Weakly expressed in brain, placenta, kidney, spleen, thymus, prostate, ovary and lymphocytes. |
| Function | Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit. |
| Protein Name | 2-(3-Amino-3-Carboxypropylhistidine Synthase Subunit 2Diphthamide Biosynthesis Protein 2Diphtheria Toxin Resistance Protein 2S-Adenosyl-L-Methionine -L-Histidine 3-Amino-3-Carboxypropyltransferase 2 |
| Database Links | Reactome: R-HSA-5358493 |
| Alternative Antibody Names | Anti-2-(3-Amino-3-Carboxypropylhistidine Synthase Subunit 2 antibodyAnti-Diphthamide Biosynthesis Protein 2 antibodyAnti-Diphtheria Toxin Resistance Protein 2 antibodyAnti-S-Adenosyl-L-Methionine -L-Histidine 3-Amino-3-Carboxypropyltransferase 2 antibodyAnti-DPH2 antibodyAnti-DPH2L2 antibody |
Information sourced from Uniprot.org
