Anti-DOT1L antibody (1-100) [S7MR] (STJ11101407)

Name: Anti-DOT1L antibody (1-100) [S7MR] (STJ11101407)
SKU: STJ11101407
Availability: InStock

⇓ Datasheet ⇓ SDS Citations

SPECIFICATIONS

ClonalityMonoclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11101407

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Short Description	Rabbit monoclonal Dot1L/KMT4 (1-100) antibody for use in WB, IP and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IP/ELISA
Host	Rabbit
Reactivity	Human/Mouse
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	S7MR
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cells ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	DOT1L
Gene ID	84444
Uniprot ID	DOT1L_HUMAN
Immunogen Region	1-100
Immunogen Sequence	MGEKLELRLKSPVGAEPAVY PWPLPVYDKHHDAAHEIIET IRWVCEEIPDLKLAMENYVL IDYDTKSFESMQRLCDKYNR AIDSIHQLWKGTTQPMKLNT
Specificity	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Dot1L/KMT4 (NP_115871.1).

Function	Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
Protein Name	Histone-Lysine N-Methyltransferase - H3 Lysine-79 Specific Dot1-Like Protein Histone H3-K79 Methyltransferase H3-K79-Hmtase Lysine N-Methyltransferase 4
Database Links	Reactome: R-HSA-3214841
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Histone-Lysine N-Methyltransferase - H3 Lysine-79 Specific antibody Anti-Dot1-Like Protein antibody Anti-Histone H3-K79 Methyltransferase antibody Anti-H3-K79-Hmtase antibody Anti-Lysine N-Methyltransferase 4 antibody Anti-DOT1L antibody Anti-KIAA1814 antibody Anti-KMT4 antibody

Information sourced from Uniprot.org