Host: | Rabbit |
Applications: | WB/IP/ELISA |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Monoclonal |
Clone ID : | S7MR |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:1000IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | DOT1L |
Gene ID: | 84444 |
Uniprot ID: | DOT1L_HUMAN |
Immunogen Region: | 1-100 |
Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Dot1L/KMT4 (NP_115871.1). |
Immunogen Sequence: | MGEKLELRLKSPVGAEPAVY PWPLPVYDKHHDAAHEIIET IRWVCEEIPDLKLAMENYVL IDYDTKSFESMQRLCDKYNR AIDSIHQLWKGTTQPMKLNT |
Function | Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. |
Protein Name | Histone-Lysine N-Methyltransferase - H3 Lysine-79 SpecificDot1-Like ProteinHistone H3-K79 MethyltransferaseH3-K79-HmtaseLysine N-Methyltransferase 4 |
Database Links | Reactome: R-HSA-3214841 |
Cellular Localisation | Nucleus |
Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase - H3 Lysine-79 Specific antibodyAnti-Dot1-Like Protein antibodyAnti-Histone H3-K79 Methyltransferase antibodyAnti-H3-K79-Hmtase antibodyAnti-Lysine N-Methyltransferase 4 antibodyAnti-DOT1L antibodyAnti-KIAA1814 antibodyAnti-KMT4 antibody |
Information sourced from Uniprot.org