Anti-DOT1L antibody (1-100) [S7MR] (STJ11101407)

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STJ11101407
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Host: Rabbit
Applications: WB/IP/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : S7MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cells
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DOT1L
Gene ID: 84444
Uniprot ID: DOT1L_HUMAN
Immunogen Region: 1-100
Specificity: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Dot1L/KMT4 (NP_115871.1).
Immunogen Sequence: MGEKLELRLKSPVGAEPAVY PWPLPVYDKHHDAAHEIIET IRWVCEEIPDLKLAMENYVL IDYDTKSFESMQRLCDKYNR AIDSIHQLWKGTTQPMKLNT
Function Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
Protein Name Histone-Lysine N-Methyltransferase - H3 Lysine-79 Specific
Dot1-Like Protein
Histone H3-K79 Methyltransferase
H3-K79-Hmtase
Lysine N-Methyltransferase 4
Database Links Reactome: R-HSA-3214841
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Histone-Lysine N-Methyltransferase - H3 Lysine-79 Specific antibody
Anti-Dot1-Like Protein antibody
Anti-Histone H3-K79 Methyltransferase antibody
Anti-H3-K79-Hmtase antibody
Anti-Lysine N-Methyltransferase 4 antibody
Anti-DOT1L antibody
Anti-KIAA1814 antibody
Anti-KMT4 antibody

Information sourced from Uniprot.org