Western blot of human adrenal medulla lysate showing specific immunolabeling of the ~75 kDa DBH protein.

Anti-Dopamine Beta-Hydroxylase antibody (N-Term) (STJA0003615)

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STJA0003615-100
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Host: Sheep
Applications: WB
Reactivity: Human/Non-Human Primates
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Sheep polyclonal antibody anti-Dopamine beta-Hydroxylase (N-Term) is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: This antibody was antigen affinity purified from pooled serum.
Dilution Range: WB 1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DBH
Gene ID: 1621
Uniprot ID: DOPO_HUMAN
Immunogen Region: N-Term
Immunogen: Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH.
Post Translational Modifications N-glycosylated. Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form.
Function Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters.
Protein Name Dopamine Beta-Hydroxylase
Dopamine Beta-Monooxygenase Cleaved Into - Soluble Dopamine Beta-Hydroxylase
Database Links Reactome: R-HSA-209905
Cellular Localisation Soluble Dopamine Beta-Hydroxylase: Cytoplasmic Vesicle
Secretory Vesicle Lumen
Cytoplasmic Vesicle
Secretory Vesicle
Chromaffin Granule Lumen
Secreted
Secretory Vesicle Membrane
Single-Pass Type Ii Membrane Protein
Chromaffin Granule Membrane
Alternative Antibody Names Anti-Dopamine Beta-Hydroxylase antibody
Anti-Dopamine Beta-Monooxygenase Cleaved Into - Soluble Dopamine Beta-Hydroxylase antibody
Anti-DBH antibody

Information sourced from Uniprot.org

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