| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DOK2 (1-260) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DOK2 |
| Gene ID: |
9046 |
| Uniprot ID: |
DOK2_HUMAN |
| Immunogen Region: |
1-260 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DOK2 (NP_003965.2). |
| Immunogen Sequence: |
MGDGAVKQGFLYLQQQQTFG KKWRRFGASLYGGSDCALAR LELQEGPEKPRRCEAARKVI RLSDCLRVAEAGGEASSPRD TSAFFLETKERLYLLAAPAA ERGDWVQAICLLAFPGQRKE LSGPEGKQSRPCMEENELYS SAVTVGPHKEFAVTMRPTEA SERCHLRGSYTLRAGESALE LWGGPEPGTQLYDWPYRFLR RFGRDKVTFSFEAGRRCVSG EGNFEFETRQGNEIFLALE |
| Tissue Specificity | Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver. |
| Post Translational Modifications | On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP. Phosphorylated on tyrosine residues by TEK/TIE2. |
| Function | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation. |
| Protein Name | Docking Protein 2Downstream Of Tyrosine Kinase 2P56(Dok-2 |
| Database Links | Reactome: R-HSA-210993Reactome: R-HSA-8853659 |
| Alternative Antibody Names | Anti-Docking Protein 2 antibodyAnti-Downstream Of Tyrosine Kinase 2 antibodyAnti-P56(Dok-2 antibodyAnti-DOK2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
