Anti-DOK1 antibody [R04-2Y2] (STJA0037382)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human DOK1
General Information
| Short Description | Rabbit monoclonal anti-DOK1 for use in WB, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R04-2Y2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | DOK1 |
| Gene ID | 1796 |
| Uniprot ID | DOK1_HUMAN |
| Immunogen | A synthesized peptide derived from human DOK1 |
Additional Info
| Tissue Specificity | Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer. |
| Post Translational Modifications | Constitutively tyrosine-phosphorylated. Phosphorylated by TEC. Phosphorylated by LYN. Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS. |
| Function | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. |
| Protein Name | Docking Protein 1Downstream Of Tyrosine Kinase 1P62(DokPp62 |
| Database Links | Reactome: R-HSA-8849469Reactome: R-HSA-8853659 |
| Cellular Localisation | Isoform 1: CytoplasmNucleusIsoform 3: CytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-Docking Protein 1 antibodyAnti-Downstream Of Tyrosine Kinase 1 antibodyAnti-P62(Dok antibodyAnti-Pp62 antibodyAnti-DOK1 antibody |
Information sourced from Uniprot.org