Anti-DOCK7 antibody (100-200) (STJ119358)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DOCK7 (100-200) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DOCK7 |
| Gene ID | 85440 |
| Uniprot ID | DOCK7_HUMAN |
| Immunogen Region | 100-200 |
| Immunogen Sequence | VSAVPEESEMDPHVRDCIRS YTEDWAIVIRKYHKLGTGFN PNTLDKQKERQKGLPKQVFE SDEAPDGNSYQDDQDDLKRR SMSIDDTPRGSWACSIFDLK N |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human DOCK7 (NP_001354490.1). |
Additional Info
| Tissue Specificity | Widely expressed. |
| Function | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization. As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. Has a role in pigmentation. Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation.negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3. |
| Protein Name | Dedicator Of Cytokinesis Protein 7 |
| Database Links | Reactome: R-HSA-8875555Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-983231 |
| Cellular Localisation | Cell ProjectionAxonEnriched In The Developing Axons Of Hippocampal Neurons |
| Alternative Antibody Names | Anti-Dedicator Of Cytokinesis Protein 7 antibodyAnti-DOCK7 antibodyAnti-KIAA1771 antibody |
Information sourced from Uniprot.org