| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DOCK7 (100-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DOCK7 |
| Gene ID: |
85440 |
| Uniprot ID: |
DOCK7_HUMAN |
| Immunogen Region: |
100-200 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human DOCK7 (NP_001354490.1). |
| Immunogen Sequence: |
VSAVPEESEMDPHVRDCIRS YTEDWAIVIRKYHKLGTGFN PNTLDKQKERQKGLPKQVFE SDEAPDGNSYQDDQDDLKRR SMSIDDTPRGSWACSIFDLK N |
| Tissue Specificity | Widely expressed. |
| Function | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization. As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. Has a role in pigmentation. Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation.negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3. |
| Protein Name | Dedicator Of Cytokinesis Protein 7 |
| Database Links | Reactome: R-HSA-8875555Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-983231 |
| Cellular Localisation | Cell ProjectionAxonEnriched In The Developing Axons Of Hippocampal Neurons |
| Alternative Antibody Names | Anti-Dedicator Of Cytokinesis Protein 7 antibodyAnti-DOCK7 antibodyAnti-KIAA1771 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
