| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DOCK1 |
| Gene ID: | 1793 |
| Uniprot ID: | DOCK1_HUMAN |
| Immunogen Region: | 1766-1865 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1766-1865 of human DOCK1 (NP_001371.1). |
| Immunogen Sequence: | QTPPPVTPRAKLSFSMQSSL ELNGMTGADVADVPPPLPLK GSVADYGNLMENQDLLGSPT PPPPPPHQRHLPPPLPSKTP PPPPPKTTRKQTSVDSGIVQ |
| Tissue Specificity | Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon. |
| Function | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. |
| Protein Name | Dedicator Of Cytokinesis Protein 1180 Kda Protein Downstream Of CrkDock180 |
| Database Links | Reactome: R-HSA-2029482Reactome: R-HSA-418885Reactome: R-HSA-4420097Reactome: R-HSA-8849471Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013408Reactome: R-HSA-9664422Reactome: R-HSA-983231 |
| Cellular Localisation | CytoplasmMembraneRecruited To Membranes Via Its Interaction With Phosphatidylinositol 345-Trisphosphate |
| Alternative Antibody Names | Anti-Dedicator Of Cytokinesis Protein 1 antibodyAnti-180 Kda Protein Downstream Of Crk antibodyAnti-Dock180 antibodyAnti-DOCK1 antibody |
Information sourced from Uniprot.org
