| Short Description : | Rabbit polyclonal anti-Doc2b (Internal Region) for use in IHC in Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC |
| Host: | Rabbit |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | IgG purified |
| Dilution Range: | IHC. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications. |
| Formulation: | Lyophilised |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | Doc2b |
| Gene ID: | 13447 |
| Uniprot ID: | DOC2B_MOUSE |
| Immunogen: | A synthetic peptide from internal region of rat Doc2b conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region: | Internal Region |
| Specificity: | Specific for DOC2B. |
| Function | Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes. |
| Protein Name | Double C2-Like Domain-Containing Protein BetaDoc2-Beta |
| Database Links | |
| Cellular Localisation | CytoplasmCytoplasmic GranuleCell MembranePeripheral Membrane ProteinTranslocates To The Plasma Membrane In A Calcium-Dependent Manner |
| Alternative Antibody Names | Anti-Double C2-Like Domain-Containing Protein Beta antibodyAnti-Doc2-Beta antibodyAnti-Doc2b antibody |
Information sourced from Uniprot.org