Anti-Doc2b antibody (Internal Region) (STJ13101020)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from internal region of rat Doc2b conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-Doc2b (Internal Region) for use in IHC in Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC. A concentration of 10-50 ยตg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Doc2b |
| Gene ID | 13447 |
| Uniprot ID | DOC2B_MOUSE |
| Immunogen | A synthetic peptide from internal region of rat Doc2b conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | Internal Region |
| Specificity | Specific for DOC2B. |
Additional Info
| Function | Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes. |
| Protein Name | Double C2-Like Domain-Containing Protein BetaDoc2-Beta |
| Database Links | |
| Cellular Localisation | CytoplasmCytoplasmic GranuleCell MembranePeripheral Membrane ProteinTranslocates To The Plasma Membrane In A Calcium-Dependent Manner |
| Alternative Antibody Names | Anti-Double C2-Like Domain-Containing Protein Beta antibodyAnti-Doc2-Beta antibodyAnti-Doc2b antibody |
Information sourced from Uniprot.org