| Host: | Goat |
| Applications: | Pep-ELISA/IHC |
| Reactivity: | Human/Mouse/Rat/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Goat polyclonal antibody anti-DOC2A (233-246) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:16000. WB: Preliminary experiments gave an approx 50kDa band in Human, Mouse and Rat Brain lysates after 0.3 µg/ml antibody staining. Please note that currently we cannot find an explanation in t |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | DOC2A |
| Gene ID: | 8448 |
| Uniprot ID: | DOC2A_HUMAN |
| Immunogen Region: | 233-246 |
| Accession Number: | NP_003577.2 |
| Immunogen Sequence: | SCYLKELEQAEQGQ |
| Function | Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. |
| Protein Name | Double C2-Like Domain-Containing Protein Alpha Doc2 Doc2-Alpha |
| Cellular Localisation | Lysosome Cytoplasmic Vesicle Secretory Vesicle Synaptic Vesicle Membrane Peripheral Membrane Protein Synapse Synaptosome |
| Alternative Antibody Names | Anti-Double C2-Like Domain-Containing Protein Alpha antibody Anti-Doc2 antibody Anti-Doc2-Alpha antibody Anti-DOC2A antibody |
Information sourced from Uniprot.org
