| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-2 deoxynucleoside 5 phosphate N-hydrolase 1 (1-50 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DNPH1 |
| Gene ID: | 10591 |
| Uniprot ID: | DNPH1_HUMAN |
| Immunogen Region: | 1-50 aa |
| Specificity: | RCL Polyclonal Antibody detects endogenous levels of RCL protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human RCL at the amino acid range 1-50 |
| Function | Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the second step in that pathway, the hydrolysis of the N-glycosidic bond in hmdUMP, degrading this cytotoxic nucleotide to avoid its genomic integration. |
| Protein Name | 5-Hydroxymethyl-Dump N-Hydrolase2'-Deoxynucleoside 5'-Phosphate N-Hydrolase 1C-Myc-Responsive Protein Rcl |
| Database Links | Reactome: R-HSA-74259 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-5-Hydroxymethyl-Dump N-Hydrolase antibodyAnti-2'-Deoxynucleoside 5'-Phosphate N-Hydrolase 1 antibodyAnti-C-Myc-Responsive Protein Rcl antibodyAnti-DNPH1 antibodyAnti-C6orf108 antibodyAnti-RCL antibody |
Information sourced from Uniprot.org