Anti-DNPH1 antibody (1-50 aa) (STJ95397)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human RCL at the amino acid range 1-50
General Information
| Short Description | Rabbit polyclonal anti-2 deoxynucleoside 5 phosphate N-hydrolase 1 (1-50 aa) for use in WB and IHC in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DNPH1 |
| Gene ID | 10591 |
| Uniprot ID | DNPH1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human RCL at the amino acid range 1-50 |
| Immunogen Region | 1-50 aa |
| Specificity | RCL Polyclonal Antibody detects endogenous levels of RCL protein. |
Additional Info
| Function | Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the second step in that pathway, the hydrolysis of the N-glycosidic bond in hmdUMP, degrading this cytotoxic nucleotide to avoid its genomic integration. |
| Protein Name | 5-Hydroxymethyl-Dump N-Hydrolase2'-Deoxynucleoside 5'-Phosphate N-Hydrolase 1C-Myc-Responsive Protein Rcl |
| Database Links | Reactome: R-HSA-74259 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-5-Hydroxymethyl-Dump N-Hydrolase antibodyAnti-2'-Deoxynucleoside 5'-Phosphate N-Hydrolase 1 antibodyAnti-C-Myc-Responsive Protein Rcl antibodyAnti-DNPH1 antibodyAnti-C6orf108 antibodyAnti-RCL antibody |
Information sourced from Uniprot.org