Anti-DNASE2 antibody (STJA0008014)

SKU:
STJA0008014
£48.00 - £252.00
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Deoxyribonuclease-2-alpha is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DNASE2
Gene ID: 1777
Uniprot ID: DNS2A_HUMAN
Specificity: This antibody detects endogenous levels of DNASE2 at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human DNASE2
Post Translational Modifications Glycosylated. Genetic variations that affect N-glycosylation sites reduce activity, but enzymatic deglycosylation has no effect.
Function Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells.
Protein Name Deoxyribonuclease-2-Alpha
Acid Dnase
Deoxyribonuclease Ii Alpha
Dnase Ii Alpha
Lysosomal Dnase Ii
R31240_2
Database Links Reactome: R-HSA-432720
Cellular Localisation Lysosome
Alternative Antibody Names Anti-Deoxyribonuclease-2-Alpha antibody
Anti-Acid Dnase antibody
Anti-Deoxyribonuclease Ii Alpha antibody
Anti-Dnase Ii Alpha antibody
Anti-Lysosomal Dnase Ii antibody
Anti-R31240_2 antibody
Anti-DNASE2 antibody
Anti-DNASE2A antibody
Anti-DNL2 antibody

Information sourced from Uniprot.org

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