| Short Description : | Rabbit polyclonal antibody anti-DNA polymerase eta (200-300) is suitable for use in ELISA and Western Blot research applications. |
| Applications: | ELISA/WB |
| Host: | Rabbit |
| Reactivity: | S.cerevisiae |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 0.70-0.98 µg/µl |
| Purification: | Affinity Purified |
| Dilution Range: | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000 |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Immunogen: | Synthetic peptide taken within amino acid region 200-300 on Chain A, Yeast DNA polymerase Eta. |
| Immunogen Region: | 200-300 |
| Background | DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. Efficiently incorporates nucleotides opposite to other UV or oxidative DNA damages like O (6)-methylguanine, 7, 8-dihydro-8-oxoguanine, 2, 6-diamino-4-hydroxy-5-formamidopyrimidine of 2 NA-deoxyguanosine (FaPydG) , or p-benzoquinone DNA adducts. |
Information sourced from Uniprot.org