| Host: |
Rabbit |
| Applications: |
WB/IP/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
LIG3 |
| Gene ID: |
3980 |
| Uniprot ID: |
DNLI3_HUMAN |
| Immunogen Region: |
730-1009 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 730-1009 of human DNA Ligase III/LIG3 (NP_039269.2). |
| Immunogen Sequence: |
AGGHDDATLARLQNELDMVK ISKDPSKIPSWLKVNKIYYP DFIVPDPKKAAVWEITGAEF SKSEAHTADGISIRFPRCTR IRDDKDWKSATNLPQLKELY QLSKEKADFTVVAGDEGSST TGGSSEENKGPSGSAVSRKA PSKPSASTKKAEGKLSNSNS KDGNMQTAKPSAMKVGEKLA TKSSPVKVGEKRKAADETLC QTKVLLDIFTGVRLYLPPST PDFSRLRRYFVAFDGDLVQ |
| Tissue Specificity | Testis, thymus, prostate and heart. |
| Function | Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair. |
| Protein Name | Dna Ligase 3Dna Ligase IiiPolydeoxyribonucleotide Synthase Atp 3 |
| Database Links | Reactome: R-HSA-110381Reactome: R-HSA-5649702Reactome: R-HSA-5685939Reactome: R-HSA-5696397Reactome: R-HSA-6782210 |
| Cellular Localisation | Isoform 1: MitochondrionContains An N-Terminal Mitochondrial Transit PeptideIsoform 2: MitochondrionIsoform 3: NucleusLacks The N-Terminal Mitochondrial Transit PeptideIsoform 4: Nucleus |
| Alternative Antibody Names | Anti-Dna Ligase 3 antibodyAnti-Dna Ligase Iii antibodyAnti-Polydeoxyribonucleotide Synthase Atp 3 antibodyAnti-LIG3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
