Host: |
Rabbit |
Applications: |
WB/IHC-P/IF/ICC/ELISA |
Reactivity: |
Human/Mouse/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
Purification: |
Affinity purification |
Concentration: |
Lot specific |
Dilution Range: |
WB:1:500-1:2000IHC-P:1:50-1:100IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
DLST |
Gene ID: |
1743 |
Uniprot ID: |
ODO2_HUMAN |
Immunogen Region: |
1-290 |
Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human DLST (NP_001924.2). |
Immunogen Sequence: |
PAKAKPAEAPAAAAPKAEPT AAAVPPPAAPIPTQMPPVPS PSQPPSGKPVSAVKPTVAPP LAEPGAGKGLRSEHREKMNR MRQRIAQRLKEAQNTCAMLT T |
Function | Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. |
Protein Name | Dihydrolipoyllysine-Residue Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex - Mitochondrial2-Oxoglutarate Dehydrogenase Complex Component E2Ogdc-E2Dihydrolipoamide Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase ComplexE2k |
Database Links | Reactome: R-HSA-6783984Reactome: R-HSA-9853506Reactome: R-HSA-9857492Reactome: R-HSA-9858328 |
Cellular Localisation | Mitochondrion MatrixNucleusMainly Localizes In The MitochondrionA Small Fraction Localizes To The NucleusWhere The 2-Oxoglutarate Dehydrogenase Complex Is Required For Histone Succinylation |
Alternative Antibody Names | Anti-Dihydrolipoyllysine-Residue Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex - Mitochondrial antibodyAnti-2-Oxoglutarate Dehydrogenase Complex Component E2 antibodyAnti-Ogdc-E2 antibodyAnti-Dihydrolipoamide Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex antibodyAnti-E2k antibodyAnti-DLST antibodyAnti-DLTS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance