Anti-DISC1 antibody (802-852 aa) (STJ13101057)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 802-852 of mouse DISC1 conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-DISC1 (802-852 aa) for use in IHC and WB in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Disc1 |
| Gene ID | 244667 |
| Uniprot ID | DISC1_MOUSE |
| Immunogen | A synthetic peptide from aa region 802-852 of mouse DISC1 conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | 802-852 aa |
| Specificity | Specific for DISC1. |
Additional Info
| Post Translational Modifications | Ubiquitinated. Ubiquitination with 'Lys-48'-linked polyubiquitin chains leads to its proteasomal degradation. |
| Function | Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding. Plays a role, together with PCNT, in the microtubule network formation. |
| Protein Name | Disrupted In Schizophrenia 1 Homolog |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonMitochondrionMicrotubule Organizing CenterCentrosomePostsynaptic DensityColocalizes With Ndel1 In The Perinuclear Region And The CentrosomeLocalizes To Punctate Cytoplasmic Foci Which Overlap In Part With MitochondriaColocalizes With Pcnt At The Centrosome |
| Alternative Antibody Names | Anti-Disrupted In Schizophrenia 1 Homolog antibodyAnti-Disc1 antibody |
Information sourced from Uniprot.org