| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Type II iodothyronine deiodinase is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DIO2 |
| Gene ID: | 1734 |
| Uniprot ID: | IOD2_HUMAN |
| Specificity: | IOD2 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Post Translational Modifications | Ubiquitinated by MARCHF6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33. |
| Function | Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. |
| Protein Name | Type Ii Iodothyronine Deiodinase5diiDioiiType 2 DiType-Ii 5'-Deiodinase |
| Database Links | Reactome: R-HSA-350864Reactome: R-HSA-9844594 |
| Cellular Localisation | MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Type Ii Iodothyronine Deiodinase antibodyAnti-5dii antibodyAnti-Dioii antibodyAnti-Type 2 Di antibodyAnti-Type-Ii 5'-Deiodinase antibodyAnti-DIO2 antibodyAnti-ITDI2 antibodyAnti-TXDI2 antibody |
Information sourced from Uniprot.org