| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (216-266 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DHX16 |
| Gene ID: |
8449 |
| Uniprot ID: |
DHX16_HUMAN |
| Immunogen Region: |
216-266 aa |
| Specificity: |
This antibody detects endogenous levels of DHX16 at Human |
| Immunogen: |
Synthesized peptide derived from the human DHX16 at the amino acid range 216-266 |
| Function | Required for pre-mRNA splicing as component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Plays also a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA. Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses. |
| Protein Name | Pre-Mrna-Splicing Factor Atp-Dependent Rna Helicase Dhx16Atp-Dependent Rna Helicase #3Deah-Box Protein 16 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleoplasmCytoplasm |
| Alternative Antibody Names | Anti-Pre-Mrna-Splicing Factor Atp-Dependent Rna Helicase Dhx16 antibodyAnti-Atp-Dependent Rna Helicase #3 antibodyAnti-Deah-Box Protein 16 antibodyAnti-DHX16 antibodyAnti-DBP2 antibodyAnti-DDX16 antibodyAnti-KIAA0577 antibodyAnti-PRP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
