| Function | Required for pre-mRNA splicing as component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Plays also a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA. Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses. |
| Protein Name | Pre-Mrna-Splicing Factor Atp-Dependent Rna Helicase Dhx16Atp-Dependent Rna Helicase #3Deah-Box Protein 16 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleoplasmCytoplasm |
| Alternative Antibody Names | Anti-Pre-Mrna-Splicing Factor Atp-Dependent Rna Helicase Dhx16 antibodyAnti-Atp-Dependent Rna Helicase #3 antibodyAnti-Deah-Box Protein 16 antibodyAnti-DHX16 antibodyAnti-DBP2 antibodyAnti-DDX16 antibodyAnti-KIAA0577 antibodyAnti-PRP2 antibody |
Information sourced from Uniprot.org
