Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Rat/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (216-266 aa) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | DHX16 |
Gene ID: | 8449 |
Uniprot ID: | DHX16_HUMAN |
Immunogen Region: | 216-266 aa |
Specificity: | This antibody detects endogenous levels of DHX16 at Human |
Immunogen: | Synthesized peptide derived from the human DHX16 at the amino acid range 216-266 |
Function | Required for pre-mRNA splicing as component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Plays also a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA. Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses. |
Protein Name | Pre-Mrna-Splicing Factor Atp-Dependent Rna Helicase Dhx16 Atp-Dependent Rna Helicase #3 Deah-Box Protein 16 |
Database Links | Reactome: R-HSA-72163 |
Cellular Localisation | Nucleus Nucleoplasm Cytoplasm |
Alternative Antibody Names | Anti-Pre-Mrna-Splicing Factor Atp-Dependent Rna Helicase Dhx16 antibody Anti-Atp-Dependent Rna Helicase #3 antibody Anti-Deah-Box Protein 16 antibody Anti-DHX16 antibody Anti-DBP2 antibody Anti-DDX16 antibody Anti-KIAA0577 antibody Anti-PRP2 antibody |
Information sourced from Uniprot.org