| Function | 2-oxoadipate dehydrogenase (E1a) component of the 2-oxoadipate dehydrogenase complex (OADHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoadipate (alpha-ketoadipate) to glutaryl-CoA and CO(2) catalyzed by the whole OADHC. Catalyzes the irreversible decarboxylation of 2-oxoadipate via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST) (Probable). Can catalyze the decarboxylation of 2-oxoglutarate in vitro, but at a much lower rate than 2-oxoadipate. Responsible for the last step of L-lysine, L-hydroxylysine and L-tryptophan catabolism with the common product being 2-oxoadipate (Probable). |
| Protein Name | 2-Oxoadipate Dehydrogenase Complex Component E1E1aOadc-E1Oadh-E12-Oxoadipate Dehydrogenase - MitochondrialAlpha-Ketoadipate DehydrogenaseAlpha-Kadh-E1Dehydrogenase E1 And Transketolase Domain-Containing Protein 1Probable 2-Oxoglutarate Dehydrogenase E1 Component Dhktd1 - Mitochondrial |
| Database Links | Reactome: R-HSA-9858328 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-2-Oxoadipate Dehydrogenase Complex Component E1 antibodyAnti-E1a antibodyAnti-Oadc-E1 antibodyAnti-Oadh-E1 antibodyAnti-2-Oxoadipate Dehydrogenase - Mitochondrial antibodyAnti-Alpha-Ketoadipate Dehydrogenase antibodyAnti-Alpha-Kadh-E1 antibodyAnti-Dehydrogenase E1 And Transketolase Domain-Containing Protein 1 antibodyAnti-Probable 2-Oxoglutarate Dehydrogenase E1 Component Dhktd1 - Mitochondrial antibodyAnti-DHTKD1 antibodyAnti-KIAA1630 antibody |
Information sourced from Uniprot.org
