• Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using DGKH Antibody. The picture on the right is blocked with the synthesized peptide.
  • Immunofluorescence analysis of HeLa cells, using DGKH Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-DGKH antibody (771-820 aa) (STJ92701)

SKU:
STJ92701

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Diacylglycerol kinase eta (771-820 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DGKH
Gene ID: 160851
Uniprot ID: DGKH_HUMAN
Immunogen Region: 771-820 aa
Specificity: DGK-Eta Polyclonal Antibody detects endogenous levels of DGK-Eta protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human DGKH at the amino acid range 771-820
Post Translational Modifications Phosphorylated. Phosphorylation does not inhibit catalytic activity.
Function Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization.
Protein Name Diacylglycerol Kinase Eta
Dag Kinase Eta
Diglyceride Kinase Eta
Dgk-Eta
Database Links Reactome: R-HSA-114508
Cellular Localisation Cytoplasm
Cell Membrane
Translocated From The Cytoplasm To Endosomes In Response To Stress Stimuli
Isoform 2 Is Rapidly Relocated Back To The Cytoplasm Upon Removal Of Stress Stimuli
Whereas Isoform 1 Exhibits Sustained Endosomal Association
Translocates From The Cytoplasm To The Cell Membrane In The Presence Of Active Gtp-Bound Form Of Hras
Alternative Antibody Names Anti-Diacylglycerol Kinase Eta antibody
Anti-Dag Kinase Eta antibody
Anti-Diglyceride Kinase Eta antibody
Anti-Dgk-Eta antibody
Anti-DGKH antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance