| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Diacylglycerol kinase beta (657-706 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 ELISA 1:40000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DGKB |
| Gene ID: | 1607 |
| Uniprot ID: | DGKB_HUMAN |
| Immunogen Region: | 657-706 aa |
| Specificity: | DGK-Beta Polyclonal Antibody detects endogenous levels of DGK-Beta protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human DGKB at the amino acid range 657-706 |
| Function | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol. Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation. Isoform 2: Does not associate with membranes but has a diacylglycerol kinase activity. |
| Protein Name | Diacylglycerol Kinase Beta Dag Kinase Beta 90 Kda Diacylglycerol Kinase Diglyceride Kinase Beta Dgk-Beta |
| Database Links | Reactome: R-HSA-114508 |
| Cellular Localisation | Postsynaptic Cell Membrane Peripheral Membrane Protein Cell Membrane Cytoplasm Translocation To The Plasma Membrane Is Induced By Phorbol Esters Isoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Diacylglycerol Kinase Beta antibody Anti-Dag Kinase Beta antibody Anti-90 Kda Diacylglycerol Kinase antibody Anti-Diglyceride Kinase Beta antibody Anti-Dgk-Beta antibody Anti-DGKB antibody Anti-DAGK2 antibody Anti-KIAA0718 antibody |
Information sourced from Uniprot.org