| Short Description : | Rabbit polyclonal DEGS1 (234-323) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:3000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DEGS1 |
| Gene ID: | 8560 |
| Uniprot ID: | DEGS1_HUMAN |
| Immunogen Region: | 234-323 |
| Immunogen Sequence: | YMFLKGHETYSYYGPLNLLT FNVGYHNEHHDFPNIPGKSL PLVRKIAAEYYDNLPHYNSW IKVLYDFVMDDTISPYSRMK RHQKGEMVLE |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 234-323 of human DEGS1 (NP_003667.1). |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Myristoylation can target the enzyme to the mitochondria leading to an increase in ceramide levels. |
| Function | Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). Catalyzes the equilibrium isomerization of retinols. |
| Protein Name | Sphingolipid Delta(4-Desaturase Des1Cell Migration-Inducing Gene 15 ProteinDegenerative Spermatocyte Homolog 1Dihydroceramide Desaturase-1Membrane Lipid DesaturaseRetinol Isomerase |
| Database Links | Reactome: R-HSA-1660661Reactome: R-HSA-6798695 |
| Cellular Localisation | Mitochondrion MembraneEndoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sphingolipid Delta(4-Desaturase Des1 antibodyAnti-Cell Migration-Inducing Gene 15 Protein antibodyAnti-Degenerative Spermatocyte Homolog 1 antibodyAnti-Dihydroceramide Desaturase-1 antibodyAnti-Membrane Lipid Desaturase antibodyAnti-Retinol Isomerase antibodyAnti-DEGS1 antibodyAnti-DES1 antibodyAnti-MLD antibodyAnti-MIG15 antibody |
Information sourced from Uniprot.org
