• Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).

Anti-DEFB4A/DEFB4B antibody (1-50 aa) (STJ196526)

SKU:
STJ196526

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Defensin beta 4A (1-50 aa) is suitable for use in Immunohistochemistry and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC-P 1:50-200
ELISA-Pep 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DEFB4A.DEFB4B
Gene ID: 100289462/1673
Uniprot ID: DFB4A_HUMAN
Immunogen Region: 1-50 aa
Specificity: This antibody detects endogenous levels of human Beta-defensin 4A
Immunogen: Synthesized peptide derived from the human Beta-defensin 4A at the amino acid range 1-50
Function Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria, with highest activity against Gram-negative bacteria. Antimicrobial activity against P.aruginosa seems to be salt-sensitive and is reduced with high salt concentrations greater than 25 mM. Also exhibits antimicrobial activity against the yeast C.albicans. Permeabilizes C.albicans cell membranes via targeting plasma membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2), thereby leading to cell fragmentation and cell death. Acts as a ligand for C-C chemokine receptor CCR6. Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells, such as immature dendritic cells and memory T cells.
Protein Name Defensin Beta 4a
Beta-Defensin 2
Bd-2
Hbd-2
Defensin - Beta 2
Skin-Antimicrobial Peptide 1
Sap1
Database Links Reactome: R-HSA-1461957
Reactome: R-HSA-1461973
Cellular Localisation Secreted
Alternative Antibody Names Anti-Defensin Beta 4a antibody
Anti-Beta-Defensin 2 antibody
Anti-Bd-2 antibody
Anti-Hbd-2 antibody
Anti-Defensin - Beta 2 antibody
Anti-Skin-Antimicrobial Peptide 1 antibody
Anti-Sap1 antibody
Anti-DEFB4A antibody
Anti-DEFB102 antibody
Anti-DEFB2 antibody
Anti-DEFB4.DEFB4B antibody

Information sourced from Uniprot.org

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