Anti-DEFB114 antibody (6-56 aa) (STJ196629)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human DB114 at the amino acid range 6-56
General Information
| Short Description | Rabbit polyclonal anti-Beta-defensin 114 (6-56 aa) for use in IHC and IF in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-200IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DEFB114 |
| Gene ID | 245928 |
| Uniprot ID | DB114_HUMAN |
| Immunogen | Synthesized peptide derived from the human DB114 at the amino acid range 6-56 |
| Immunogen Region | 6-56 aa |
| Specificity | This antibody detects endogenous levels of DB114 at Human |
Additional Info
| Function | Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. |
| Protein Name | Beta-Defensin 114Beta-Defensin 14Defb-14Defensin - Beta 114 |
| Database Links | Reactome: R-HSA-1461957Reactome: R-HSA-1461973 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Beta-Defensin 114 antibodyAnti-Beta-Defensin 14 antibodyAnti-Defb-14 antibodyAnti-Defensin - Beta 114 antibodyAnti-DEFB114 antibodyAnti-DEFB14 antibody |
Information sourced from Uniprot.org