Anti-DDX24 antibody (41-90 aa) (STJ92675)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human DDX24 at the amino acid range 41-90
General Information
| Short Description | Rabbit polyclonal anti-ATP-dependent RNA helicase DDX24 (41-90 aa) for use in IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DDX24 |
| Gene ID | 57062 |
| Uniprot ID | DDX24_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human DDX24 at the amino acid range 41-90 |
| Immunogen Region | 41-90 aa |
| Specificity | DDX24 Polyclonal Antibody detects endogenous levels of DDX24 protein. |
Additional Info
| Post Translational Modifications | Ubiquitinated by MDM2 without targeting DDX24 for proteasomal degradation. Instead, polyubiquitinated DDX24 promotes interaction with NIP7, a component of pre-rRNP processing complex, and associates with pre-rRNA molecules and pre-ribosomal particles. |
| Function | ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including pre-mRNA splicing and is thereby involved in different biological processes such as cell cycle regulation or innate immunity. Plays an inhibitory role in TP53 transcriptional activity and subsequently in TP53 controlled cell growth arrest and senescence by inhibiting its EP300 mediated acetylation. Negatively regulates cytosolic RNA-mediated innate immune signaling at least in part by affecting RIPK1/IRF7 interactions. Alternatively, possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation. Plays an essential role in cell cycle regulation in vascular smooth muscle cells by interacting with and regulating FANCA (Fanconi anemia complementation group A) mRNA. (Microbial infection) Plays a positive role in HIV-1 infection by promoting Rev-dependent nuclear export of viral RNAs and their packaging into virus particles. |
| Protein Name | Atp-Dependent Rna Helicase Ddx24Dead Box Protein 24 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Atp-Dependent Rna Helicase Ddx24 antibodyAnti-Dead Box Protein 24 antibodyAnti-DDX24 antibody |
Information sourced from Uniprot.org