| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DCTN6 |
| Gene ID: | 10671 |
| Uniprot ID: | DCTN6_HUMAN |
| Immunogen Region: | 1-190 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human DCTN6 (NP_006562.1). |
| Immunogen Sequence: | MAEKTQKSVKIAPGAVVCVE SEIRGDVTIGPRTVIHPKAR IIAEAGPIVIGEGNLIEEQA LIINAYPDNITPDTEDPEPK PMIIGTNNVFEVGCYSQAMK MGDNNVIESKAYVGRNVILT SGCIIGACCNLNTFEVIPEN TVIYGADCLRRVQTERPQPQ TLQLDFLMKILPNYHHLKKT MKGSSTPVKN |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylation at Thr-186 by CDK1 during mitotic prometaphase creates a binding site for PLK1 that facilitates its recruitment to kinetochores. |
| Function | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. |
| Protein Name | Dynactin Subunit 6 Dynactin Subunit P27 Protein Ws-3 |
| Database Links | Reactome: R-HSA-2132295 Reactome: R-HSA-3371497 Reactome: R-HSA-6807878 Reactome: R-HSA-6811436 |
| Cellular Localisation | Cytoplasm Cytoskeleton Chromosome Centromere Kinetochore |
| Alternative Antibody Names | Anti-Dynactin Subunit 6 antibody Anti-Dynactin Subunit P27 antibody Anti-Protein Ws-3 antibody Anti-DCTN6 antibody Anti-WS3 antibody |
Information sourced from Uniprot.org