| Short Description : | Rabbit polyclonal anti-Lariat debranching enzyme (230-280 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DBR1 |
| Gene ID: | 51163 |
| Uniprot ID: | DBR1_HUMAN |
| Immunogen: | Synthesized peptide derived from the human DBR1 at the amino acid range 230-280 |
| Immunogen Region: | 230-280 aa |
| Specificity: | This antibody detects endogenous levels of DBR1 at Human/Mouse |
| Function | Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover. Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis and have an antiviral cell-intrinsic defense function in the brainstem. |
| Protein Name | Lariat Debranching Enzyme |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lariat Debranching Enzyme antibodyAnti-DBR1 antibody |
Information sourced from Uniprot.org
