Anti-DBN1 antibody (484-534 aa) (STJ196046)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human DREB at the amino acid range 484-534
General Information
| Short Description | Rabbit polyclonal anti-Drebrin (484-534 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DBN1 |
| Gene ID | 1627 |
| Uniprot ID | DREB_HUMAN |
| Immunogen | Synthesized peptide derived from the human DREB at the amino acid range 484-534 |
| Immunogen Region | 484-534 aa |
| Specificity | This antibody detects endogenous levels of DREB at Human/Mouse/Rat |
Additional Info
| Function | Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections. Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS. Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines. Involved in memory-related synaptic plasticity in the hippocampus. |
| Protein Name | DrebrinDevelopmentally-Regulated Brain Protein |
| Database Links | Reactome: R-HSA-9013405Reactome: R-HSA-9013407Reactome: R-HSA-9013418Reactome: R-HSA-9013422 |
| Cellular Localisation | CytoplasmCell ProjectionDendriteCell CortexCell JunctionGrowth ConeIn The Absence Of AntigenEvenly Distributed Throughout Subcortical Regions Of The T-Cell Membrane And CytoplasmIn The Presence Of AntigenDistributes To The Immunological Synapse Forming At The T-Cell-Apc Contact AreaWhere It Localizes At The Peripheral And Distal Supramolecular Activation Clusters (Smac)Colocalized With Rufy3 And F-Actin At The Transitional Domain Of The Axonal Growth Cone |
| Alternative Antibody Names | Anti-Drebrin antibodyAnti-Developmentally-Regulated Brain Protein antibodyAnti-DBN1 antibodyAnti-D0S117E antibody |
Information sourced from Uniprot.org