Anti-DAGLA antibody (900-980 aa) (STJ191427)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 900-980
General Information
| Short Description | Rabbit polyclonal anti-Diacylglycerol lipase-alpha (900-980 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DAGLA |
| Gene ID | 747 |
| Uniprot ID | DGLA_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 900-980 |
| Immunogen Region | 900-980 aa |
| Specificity | DGLA Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Phosphorylated at Ser-782 and Ser-808 by CAMK2A.phosphorylation by CAMK2A inhibits diacylglycerol lipase activity. |
| Function | Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG. Has negligible activity against other lipids including monoacylglycerols and phospholipids. Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Also regulates neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation. |
| Protein Name | Diacylglycerol Lipase-AlphaDagl-AlphaDgl-AlphaNeural Stem Cell-Derived Dendrite RegulatorSn1-Specific Diacylglycerol Lipase Alpha |
| Database Links | Reactome: R-HSA-426048 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Density MembraneEarly Endosome MembraneCell ProjectionDendritic Spine MembraneCycles Between The Cell Surface And An Intracellular Endosomal CompartmentInternalized By Early Endosomes Via A Clathrin-Independent Pathway Before Transport Back To The Postsynaptic Membrane Surface In A Pkc-Dependent Manner |
| Alternative Antibody Names | Anti-Diacylglycerol Lipase-Alpha antibodyAnti-Dagl-Alpha antibodyAnti-Dgl-Alpha antibodyAnti-Neural Stem Cell-Derived Dendrite Regulator antibodyAnti-Sn1-Specific Diacylglycerol Lipase Alpha antibodyAnti-DAGLA antibodyAnti-C11orf11 antibodyAnti-KIAA0659 antibodyAnti-NSDDR antibody |
Information sourced from Uniprot.org