Anti-DACH2 antibody (STJA0004690)

SKU:
STJA0004690

Current Stock:
Host: Rabbit
Applications: IHC/ELISA
Reactivity: Human/Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Dachshund Homolog 2 is suitable for use in Immunohistochemistry and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification: Affinity purification
Concentration: 0.6 mg/mL
Dilution Range: IHC 1:50-1:200
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: DACH2
Gene ID: 117154
Uniprot ID: DACH2_HUMAN
Immunogen: Recombinant protein of human DACH2
Function Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression. Probably binds to DNA via its DACHbox-N domain.
Protein Name Dachshund Homolog 2
Dach2
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Dachshund Homolog 2 antibody
Anti-Dach2 antibody
Anti-DACH2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance