| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CYP4V2 |
| Gene ID: |
285440 |
| Uniprot ID: |
CP4V2_HUMAN |
| Immunogen Region: |
206-525 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human CYP4V2 (NP_997235.3). |
| Immunogen Sequence: |
ICETAMGKNIGAQSNDDSEY VRAVYRMSEMIFRRIKMPWL WLDLWYLMFKEGWEHKKSLQ ILHTFTNSVIAERANEMNAN EDCRGDGRGSAPSKNKRRAF LDLLLSVTDDEGNRLSHEDI REEVDTFMFEGHDTTAAAIN WSLYLLGSNPEVQKKVDHEL DDVFGKSDRPATVEDLKKLR YLECVIKETLRLFPSVPLFA RSVSEDCEVAGYRVLKGTEA VIIPYALHRDPRYFPNPEE |
| Tissue Specificity | Broadly expressed. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, retina, retinal pigment epithelium (RPE) and lymphocytes. |
| Function | A cytochrome P450 monooxygenase involved in fatty acid metabolism in the eye. Catalyzes the omega-hydroxylation of polyunsaturated fatty acids (PUFAs) docosahexaenoate (DHA) and its precursor eicosapentaenoate (EPA), and may contribute to the homeostasis of these retinal PUFAs. Omega hydroxylates saturated fatty acids such as laurate, myristate and palmitate, the catalytic efficiency decreasing in the following order: myristate > laurate > palmitate (C14>C12>C16). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). |
| Protein Name | Cytochrome P450 4v2Docosahexaenoic Acid Omega-Hydroxylase Cyp4v2Long-Chain Fatty Acid Omega-Monooxygenase |
| Database Links | Reactome: R-HSA-211976Reactome: R-HSA-2453902 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cytochrome P450 4v2 antibodyAnti-Docosahexaenoic Acid Omega-Hydroxylase Cyp4v2 antibodyAnti-Long-Chain Fatty Acid Omega-Monooxygenase antibodyAnti-CYP4V2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
