Anti-CYP4A11/22 antibody (391-440 aa) (STJ92597)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Cytochrome P450 4A11/22 at the amino acid range 391-440
General Information
| Short Description | Rabbit polyclonal anti-Cytochrome P450 4A11 and Cytochrome P450 4A22 (391-440 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CYP4A11CYP4A22 |
| Gene ID | 1579284541 |
| Uniprot ID | CP4AB_HUMANCP4AM_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Cytochrome P450 4A11/22 at the amino acid range 391-440 |
| Immunogen Region | 391-440 aa |
| Specificity | CYP4A11/22 Polyclonal Antibody detects endogenous levels of CYP4A11/22 protein. |
Additional Info
| Function | A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids, the catalytic efficiency decreasing in the following order: dodecanoic > tetradecanoic > (9Z)-octadecenoic > (9Z,12Z)-octadecadienoic > hexadecanoic acid. Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver. Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure. Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency. May contribute to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shortening. Omega-hydroxylates (9R,10S)-epoxy-octadecanoate stereoisomer. Plays a minor role in omega-oxidation of long-chain 3-hydroxy fatty acids. Has little activity toward prostaglandins A1 and E1. |
| Protein Name | Cytochrome P450 4a1120-Hydroxyeicosatetraenoic Acid Synthase20-Hete SynthaseCyp4aiiCypiva11Cytochrome P-450hk-OmegaCytochrome P450hl-OmegaFatty Acid Omega-HydroxylaseLauric Acid Omega-HydroxylaseLong-Chain Fatty Acid Omega-Monooxygenase |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-211935Reactome: R-HSA-211958Reactome: R-HSA-211979Reactome: R-HSA-2142691Reactome: R-HSA-2142816 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 4a11 antibodyAnti-20-Hydroxyeicosatetraenoic Acid Synthase antibodyAnti-20-Hete Synthase antibodyAnti-Cyp4aii antibodyAnti-Cypiva11 antibodyAnti-Cytochrome P-450hk-Omega antibodyAnti-Cytochrome P450hl-Omega antibodyAnti-Fatty Acid Omega-Hydroxylase antibodyAnti-Lauric Acid Omega-Hydroxylase antibodyAnti-Long-Chain Fatty Acid Omega-Monooxygenase antibodyAnti-CYP4A11 antibodyAnti-CYP4A2 antibody |
Information sourced from Uniprot.org