Anti-CYP3A7 antibody (231-280 aa) (STJ92596)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Cytochrome P450 3A7 at the amino acid range 231-280
General Information
| Short Description | Rabbit polyclonal anti-Cytochrome P450 3A7 (231-280 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CYP3A7 |
| Gene ID | 100861540/1551 |
| Uniprot ID | CP3A7_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Cytochrome P450 3A7 at the amino acid range 231-280 |
| Immunogen Region | 231-280 aa |
| Specificity | CYP3A7 Polyclonal Antibody detects endogenous levels of CYP3A7 protein. |
Additional Info
| Function | A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA), a precursor in the biosynthesis of androgen and estrogen steroid hormones. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position. Mainly hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in atRA clearance during fetal development. Also involved in the oxidative metabolism of xenobiotics including anticonvulsants. |
| Protein Name | Cytochrome P450 3a7Cypiiia7Cytochrome P450-HflaP450hlp2 |
| Database Links | Reactome: R-HSA-211981 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 3a7 antibodyAnti-Cypiiia7 antibodyAnti-Cytochrome P450-Hfla antibodyAnti-P450hlp2 antibodyAnti-CYP3A7 antibody |
Information sourced from Uniprot.org