| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Cytochrome P450 2S1 (181-230 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CYP2S1 |
| Gene ID: |
29785 |
| Uniprot ID: |
CP2S1_HUMAN |
| Immunogen Region: |
181-230 aa |
| Specificity: |
CYP2S1 Polyclonal Antibody detects endogenous levels of CYP2S1 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human Cytochrome P450 2S1 at the amino acid range 181-230 |
| Function | A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids. In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs). Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage. |
| Protein Name | Cytochrome P450 2s1Cypiis1Hydroperoxy Icosatetraenoate DehydrataseThromboxane-A Synthase |
| Database Links | Reactome: R-HSA-211958Reactome: R-HSA-211981Reactome: R-HSA-211999 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 2s1 antibodyAnti-Cypiis1 antibodyAnti-Hydroperoxy Icosatetraenoate Dehydratase antibodyAnti-Thromboxane-A Synthase antibodyAnti-CYP2S1 antibodyAnti-UNQ891 antibodyAnti-PRO1906 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
