| Tissue Specificity | Widely expressed. Highest expression in heart, stomach, bladder and small intestine. |
| Post Translational Modifications | The formation of an intramolecular disulfide bond between cysteines Cys-38 and Cys-83 specifically enhances the nitrite reductase activity. |
| Function | Probable multifunctional globin with a hexacoordinated heme iron required for the catalysis of various reactions depending on redox condition of the cell as well as oxygen availability. Has a nitric oxide dioxygenase (NOD) activity and is most probably involved in cell-mediated and oxygen-dependent nitric oxide consumption. By scavenging this second messenger may regulate several biological processes including endothelium-mediated vasodilation and vascular tone. Under normoxic conditions functions as a nitric oxide dioxygenase (NOD) but under hypoxic conditions the globin may switch its function to that of a nitrite (NO2) reductase (NiR), generating nitric oxide. Could also have peroxidase and superoxide dismutase activities, detoxifying reactive oxygen species and protecting cells against oxidative stress. Also binds dioxygen with low affinity and could function as an oxygen sensor but has probably no function as a respiratory oxygen carrier. |
| Protein Name | CytoglobinHistoglobinHgbNitric Oxygen Dioxygenase CygbNodNitrite Reductase CygbPseudoperoxidase CygbStellate Cell Activation-Associated ProteinSuperoxide Dismutase Cygb |
| Database Links | Reactome: R-HSA-203615Reactome: R-HSA-8981607 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cytoglobin antibodyAnti-Histoglobin antibodyAnti-Hgb antibodyAnti-Nitric Oxygen Dioxygenase Cygb antibodyAnti-Nod antibodyAnti-Nitrite Reductase Cygb antibodyAnti-Pseudoperoxidase Cygb antibodyAnti-Stellate Cell Activation-Associated Protein antibodyAnti-Superoxide Dismutase Cygb antibodyAnti-CYGB antibodyAnti-STAP antibody |
Information sourced from Uniprot.org
