Name: Anti-Cyclin E antibody (10-176aa) [ZM121] (STJ180341)
SKU: STJ180341
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Anti-Cyclin E antibody (10-176aa) [ZM121] (STJ180341)

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STJ180341

£146.50 - £530.50

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Host:	Mouse
Applications:	IHC-P
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description :	Mouse monoclonal Cyclin E (10-176aa) antibody for use in IHC-P in human samples. Datasheet included with dilution recommendations, and related reagents.

Clonality :	Monoclonal
Clone ID :	ZM121
Conjugation:	Unconjugated
Isotype:	IgG2bk
Formulation:	Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Purification:	Affinity purified
Dilution Range:	1:50‐100
Storage Instruction:	Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.

Gene Symbol:	CCNE1
Gene ID:	898
Uniprot ID:	CCNE1_HUMAN
Immunogen Region:	10-176aa
Specificity:	Positive control: Colon carcinoma
Immunogen:	Recombinant human Cyclin E (CCNE1) protein fragment (around aa 10-176)

Tissue Specificity	Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
Post Translational Modifications	Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7. Ubiquitinated by UHRF2.appears to occur independently of phosphorylation.
Function	Essential for the control of the cell cycle at the G1/S (start) transition.
Protein Name	G1/S-Specific Cyclin-E1
Database Links	Reactome: R-HSA-1538133 Reactome: R-HSA-187577 Reactome: R-HSA-2559586 Reactome: R-HSA-390471 Reactome: R-HSA-6804116 Reactome: R-HSA-69017 Reactome: R-HSA-69200 Reactome: R-HSA-69202 Reactome: R-HSA-69205 Reactome: R-HSA-69231 Reactome: R-HSA-69563 Reactome: R-HSA-8849470 Reactome: R-HSA-9661069 Reactome: R-HSA-9706019
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-G1/S-Specific Cyclin-E1 antibody Anti-CCNE1 antibody Anti-CCNE antibody

Information sourced from Uniprot.org

Anti-Cyclin E antibody (10-176aa) [ZM121] (STJ180341)

General Information

Model	Name	Host	Clonality	Reactivity	Application
STJA0004920	Anti-Cyclin A2 antibody [SM4920] (STJA0004920)	Mouse	Monoclonal	Human	WB
STJ16101434	Anti-Cyclin D1 antibody [SP4] (STJ16101434)	Rabbit	Monoclonal	Human	IHC-P
STJ16101725	Anti-Cyclin D1 antibody [P2D11F11] (STJ16101725)	Mouse	Monoclonal	Human	IHC-P
STJ11107963	Anti-Cyclin B1 antibody [SRM13233] (STJ11107963)	Rabbit	Monoclonal	Human	WB/IP/IHC-P/ELISA
STJA0040221	Anti-Cyclin D2 antibody [PT1185R] (STJA0040221)	Rabbit	Monoclonal	Human	WB/IF/IP/ELISA