Anti-Cyclin E antibody (10-176aa) [ZM121] (STJ180341)

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STJ180341

£152.50 - £534.50

General Information
Product Properties
Target Information
Additional Info
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Host:	Mouse
Applications:	IHC-P
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Cyclin E (10-176aa) is suitable for use in Immunohistochemistry research applications.

Clonality:	Monoclonal
Clone ID:	ZM121
Conjugation:	Unconjugated
Isotype:	IgG2b/Kappa
Formulation:	Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Purification:	Affinity purified
Dilution Range:	1:50‐100
Storage Instruction:	Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.

Immunogen Region:	10-176aa
Specificity:	Positive control: Colon carcinoma
Immunogen:	Recombinant human Cyclin E (CCNE1) protein fragment (around aa 10-176)

Background

Cyclin E belongs to the highly conserved cyclin family; whose members exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Cyclin E overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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