| Short Description : | Mouse monoclonal Cyclin E (10-176aa) antibody for use in IHC-P in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC-P |
| Host: | Mouse |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | ZM121 |
| Isotype: | IgG2bk |
| Conjugation: | Unconjugated |
| Purification: | Affinity purified |
| Dilution Range: | 1:50‐100 |
| Formulation: | Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin |
| Storage Instruction: | Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C. |
| Gene Symbol: | CCNE1 |
| Gene ID: | 898 |
| Uniprot ID: | CCNE1_HUMAN |
| Immunogen: | Recombinant human Cyclin E (CCNE1) protein fragment (around aa 10-176) |
| Immunogen Region: | 10-176aa |
| Specificity: | Positive control: Colon carcinoma |
| Tissue Specificity | Highly expressed in testis and placenta. Low levels in bronchial epithelial cells. |
| Post Translational Modifications | Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7. Ubiquitinated by UHRF2.appears to occur independently of phosphorylation. |
| Function | Essential for the control of the cell cycle at the G1/S (start) transition. |
| Protein Name | G1/S-Specific Cyclin-E1 |
| Database Links | Reactome: R-HSA-1538133Reactome: R-HSA-187577Reactome: R-HSA-2559586Reactome: R-HSA-390471Reactome: R-HSA-6804116Reactome: R-HSA-69017Reactome: R-HSA-69200Reactome: R-HSA-69202Reactome: R-HSA-69205Reactome: R-HSA-69231Reactome: R-HSA-69563Reactome: R-HSA-8849470Reactome: R-HSA-9661069Reactome: R-HSA-9706019 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-G1/S-Specific Cyclin-E1 antibodyAnti-CCNE1 antibodyAnti-CCNE antibody |
Information sourced from Uniprot.org
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