| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-CXCR2 (N-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | CXCR2 |
| Gene ID: | 3579 |
| Uniprot ID: | CXCR2_HUMAN |
| Immunogen Region: | N-Term |
| Specificity: | Specific for CXCR2. |
| Immunogen: | A synthetic peptide from n-terminal region of human CXCR2 conjugated to an immunogenic carrier protein was used as the antigen. |
| Function | Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. |
| Protein Name | C-X-C Chemokine Receptor Type 2Cxc-R2Cxcr-2Cdw128bGro/Mgsa ReceptorHigh Affinity Interleukin-8 Receptor BIl-8r BIl-8 Receptor Type 2Cd Antigen Cd182 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-C-X-C Chemokine Receptor Type 2 antibodyAnti-Cxc-R2 antibodyAnti-Cxcr-2 antibodyAnti-Cdw128b antibodyAnti-Gro/Mgsa Receptor antibodyAnti-High Affinity Interleukin-8 Receptor B antibodyAnti-Il-8r B antibodyAnti-Il-8 Receptor Type 2 antibodyAnti-Cd Antigen Cd182 antibodyAnti-CXCR2 antibodyAnti-IL8RB antibody |
Information sourced from Uniprot.org
