| Host: |
Mouse |
| Applications: |
WB/ICC/IP |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Delta 1-Catenin (central Region) is suitable for use in Western Blot, Immunocytochemistry and Immunoprecipitation research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
M354 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Purification: |
Protein A Purified |
| Dilution Range: |
WB 1:1000IHCICC 1:100IP 1:50 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CTNND1 |
| Gene ID: |
1500 |
| Uniprot ID: |
CTND1_HUMAN |
| Immunogen Region: |
central Region |
| Specificity: |
The antibody detects a 110 kDa* protein corresponding to the molecular mass of Delta 1-Catenin on SDS-PAGE immunoblots of human A431 and HUVEC cells. |
| Immunogen: |
Clone (M354) was generated from a peptide that includes amino acids from the central region of human Delta 1-Catenin. This peptide sequence is highly conserved in rat and mouse Delta 1-Catenin. |
| Tissue Specificity | Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs. |
| Post Translational Modifications | Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK5. Dephosphorylated by PTPRJ. |
| Function | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. |
| Protein Name | Catenin Delta-1Cadherin-Associated Src SubstrateCasP120 CateninP120(CtnP120(Cas |
| Database Links | Reactome: R-HSA-418990Reactome: R-HSA-5218920Reactome: R-HSA-8876493Reactome: R-HSA-9762292Reactome: R-HSA-9764302Reactome: R-HSA-9833576 |
| Cellular Localisation | Cell JunctionAdherens JunctionCytoplasmNucleusCell MembraneInteraction With Glis2 Promotes Nuclear TranslocationDetected At Cell-Cell ContactsNanos1 Induces Its Translocation From Sites Of Cell-Cell Contact To The CytoplasmCdh1 Enhances Cell Membrane LocalizationIsoforms 4a And 1ab Are Excluded From The NucleusIsoform 1a: NucleusIsoform 2a: NucleusIsoform 3a: Nucleus |
| Alternative Antibody Names | Anti-Catenin Delta-1 antibodyAnti-Cadherin-Associated Src Substrate antibodyAnti-Cas antibodyAnti-P120 Catenin antibodyAnti-P120(Ctn antibodyAnti-P120(Cas antibodyAnti-CTNND1 antibodyAnti-KIAA0384 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
