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Anti-CTNND1 antibody (600-700 aa) [ABT-p120] (STJ197036)

Various whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-p120 catenin (ABT-p120) antibody. The HRP-conjugated anti- mouse IgG antibody was used to detect the antibody. Lane 1: A431 Lane 2: HEK293 Lane 3: HelaPredicted band size: 108kDaObserved band size: 110kDa
Human colon carcinoma tissue was stained with Anti-p120 catenin (ABT-p120) Antibody
Human ductal carcinoma of breast tissue was stained with Anti-p120 catenin (ABT-p120) Antibody
Human ductal carcinoma of breast tissue was stained with Anti-p120 catenin (ABT-p120) Antibody
Immunohistochemical analysis of paraffin-embedded Colon carcinoma. 1, Antibody was diluted at 1:200 (4°C overnight). 2, TRIS-EDTA of pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).
Immunohistochemical analysis of paraffin-embedded Invasive ductal breast carcinoma. 1, Antibody was diluted at 1:200 (4°C overnight). 2, TRIS-EDTA of pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).
Immunohistochemical analysis of paraffin-embedded human breast Antibody was diluted at 1:200 (4°C overnight).

Anti-CTNND1 antibody (600-700 aa) [ABT-p120] (STJ197036)

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STJ197036

£174.00 - £252.00

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Mouse
Applications:	WB/IHC/IF
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Catenin delta-1 (600-700 aa) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Monoclonal
Clone ID:	ABT-p120
Conjugation:	Unconjugated
Isotype:	IgG2bk
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Dilution Range:	IHC-P 1:100-500 WB 1:100-2000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CTNND1
Gene ID:	1500
Uniprot ID:	CTND1_HUMAN
Immunogen Region:	600-700 aa
Specificity:	This antibody detects endogenous levels of human p120 catenin. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH9.0 was highly recommended as antigen repair method in paraffin section
Immunogen:	Synthesized peptide derived from the human p120 catenin at the amino acid range 600-700

Post Translational Modifications	Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK5. Dephosphorylated by PTPRJ.
Function	Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors.
Protein Name	Catenin Delta-1 Cadherin-Associated Src Substrate Cas P120 Catenin P120(Ctn P120(Cas
Database Links	Reactome: R-HSA-418990 Reactome: R-HSA-5218920 Reactome: R-HSA-8876493 Reactome: R-HSA-9762292 Reactome: R-HSA-9764302 Reactome: R-HSA-9833576
Cellular Localisation	Cell Junction Adherens Junction Cytoplasm Nucleus Cell Membrane Interaction With Glis2 Promotes Nuclear Translocation Detected At Cell-Cell Contacts Nanos1 Induces Its Translocation From Sites Of Cell-Cell Contact To The Cytoplasm Cdh1 Enhances Cell Membrane Localization Localizes To Cell-Cell Contacts As Keratinocyte Differentiation Progresses Isoform 1a: Nucleus Isoform 2a: Nucleus Isoform 3a: Nucleus Isoform 4a: Cytoplasm Isoform 1ab: Cytoplasm
Alternative Antibody Names	Anti-Catenin Delta-1 antibody Anti-Cadherin-Associated Src Substrate antibody Anti-Cas antibody Anti-P120 Catenin antibody Anti-P120(Ctn antibody Anti-P120(Cas antibody Anti-CTNND1 antibody Anti-KIAA0384 antibody

Information sourced from Uniprot.org

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