| Host: |
Mouse |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Catenin delta-1 (600-700 aa) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
ABT-p120 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG2bk |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: |
IHC-P 1:100-500WB 1:100-2000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CTNND1 |
| Gene ID: |
1500 |
| Uniprot ID: |
CTND1_HUMAN |
| Immunogen Region: |
600-700 aa |
| Specificity: |
This antibody detects endogenous levels of human p120 catenin. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH9.0 was highly recommended as antigen repair method in paraffin section |
| Immunogen: |
Synthesized peptide derived from the human p120 catenin at the amino acid range 600-700 |
| Post Translational Modifications | Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK5. Dephosphorylated by PTPRJ. |
| Function | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. |
| Protein Name | Catenin Delta-1Cadherin-Associated Src SubstrateCasP120 CateninP120(CtnP120(Cas |
| Database Links | Reactome: R-HSA-418990Reactome: R-HSA-5218920Reactome: R-HSA-8876493Reactome: R-HSA-9762292Reactome: R-HSA-9764302Reactome: R-HSA-9833576 |
| Cellular Localisation | Cell JunctionAdherens JunctionCytoplasmNucleusCell MembraneInteraction With Glis2 Promotes Nuclear TranslocationDetected At Cell-Cell ContactsNanos1 Induces Its Translocation From Sites Of Cell-Cell Contact To The CytoplasmCdh1 Enhances Cell Membrane LocalizationIsoforms 4a And 1ab Are Excluded From The NucleusIsoform 1a: NucleusIsoform 2a: NucleusIsoform 3a: Nucleus |
| Alternative Antibody Names | Anti-Catenin Delta-1 antibodyAnti-Cadherin-Associated Src Substrate antibodyAnti-Cas antibodyAnti-P120 Catenin antibodyAnti-P120(Ctn antibodyAnti-P120(Cas antibodyAnti-CTNND1 antibodyAnti-KIAA0384 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
