| Host: | Mouse |
| Applications: | WB/IHC/IF |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Catenin delta-1 (600-700 aa) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality : | Monoclonal |
| Clone ID : | ABT-p120 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2bk |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: | IHC-P 1:100-500 WB 1:100-2000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CTNND1 |
| Gene ID: | 1500 |
| Uniprot ID: | CTND1_HUMAN |
| Immunogen Region: | 600-700 aa |
| Specificity: | This antibody detects endogenous levels of human p120 catenin. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH9.0 was highly recommended as antigen repair method in paraffin section |
| Immunogen: | Synthesized peptide derived from the human p120 catenin at the amino acid range 600-700 |
| Post Translational Modifications | Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK5. Dephosphorylated by PTPRJ. |
| Function | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. |
| Protein Name | Catenin Delta-1 Cadherin-Associated Src Substrate Cas P120 Catenin P120(Ctn P120(Cas |
| Database Links | Reactome: R-HSA-418990 Reactome: R-HSA-5218920 Reactome: R-HSA-8876493 Reactome: R-HSA-9762292 Reactome: R-HSA-9764302 Reactome: R-HSA-9833576 |
| Cellular Localisation | Cell Junction Adherens Junction Cytoplasm Nucleus Cell Membrane Interaction With Glis2 Promotes Nuclear Translocation Detected At Cell-Cell Contacts Nanos1 Induces Its Translocation From Sites Of Cell-Cell Contact To The Cytoplasm Cdh1 Enhances Cell Membrane Localization Localizes To Cell-Cell Contacts As Keratinocyte Differentiation Progresses Isoform 1a: Nucleus Isoform 2a: Nucleus Isoform 3a: Nucleus Isoform 4a: Cytoplasm Isoform 1ab: Cytoplasm |
| Alternative Antibody Names | Anti-Catenin Delta-1 antibody Anti-Cadherin-Associated Src Substrate antibody Anti-Cas antibody Anti-P120 Catenin antibody Anti-P120(Ctn antibody Anti-P120(Cas antibody Anti-CTNND1 antibody Anti-KIAA0384 antibody |
Information sourced from Uniprot.org