| Host: | Goat |
| Applications: | Pep-ELISA/WB/IHC/IF/FC |
| Reactivity: | Human/Mouse/Rat/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-CSNK1E (C-Term) is suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunofluorescence and Flow Cytometry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 48kDa band observed in nuclear lysates of cell lines A431and HeLa, and approx 45kDa in nuclear lysates of cell line K562 (calculated MW of 47.3kDa according to NP_001276841.1). |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Immunogen Region: | C-Term |
| Accession Number: | NP_001276841.1 |
| Immunogen Sequence: | PASQTSVPFDHLGK |
| Post Translational Modifications | Autophosphorylated. Partially dephosphorylated by PPP5C. May be dephosphorylated by PP1. |
| Function | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation. |
| Protein Name | Casein Kinase I Isoform EpsilonCki-EpsilonCkie |
| Database Links | Reactome: R-MMU-201688Reactome: -MMU-2565942Reactome: -MMU-380259Reactome: -MMU-380270Reactome: -MMU-380284Reactome: -MMU-380320Reactome: -MMU-5620912Reactome: -MMU-6791226Reactome: -MMU-8854518 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Casein Kinase I Isoform Epsilon antibodyAnti-Cki-Epsilon antibodyAnti-Ckie antibodyAnti-Csnk1e antibody |
Information sourced from Uniprot.org