Anti-CSNK1E antibody (276-325 aa) (STJ92016)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CKI-epsilon at the amino acid range 276-325
General Information
| Short Description | Rabbit polyclonal anti-Casein kinase I isoform epsilon (276-325 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CSNK1E |
| Gene ID | 1454 |
| Uniprot ID | KC1E_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CKI-epsilon at the amino acid range 276-325 |
| Immunogen Region | 276-325 aa |
| Specificity | Casein Kinase I Epsilon Polyclonal Antibody detects endogenous levels of Casein Kinase I Epsilon protein. |
Additional Info
| Post Translational Modifications | Autophosphorylated. Partially dephosphorylated by PPP5C. May be dephosphorylated by PP1. |
| Function | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling. Phosphorylates DVL1. Phosphorylates DVL2. Phosphorylates NEDD9/HEF1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation. |
| Protein Name | Casein Kinase I Isoform EpsilonCki-EpsilonCkie |
| Database Links | Reactome: R-HSA-201688Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-400253Reactome: R-HSA-5620912Reactome: R-HSA-6791226Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Casein Kinase I Isoform Epsilon antibodyAnti-Cki-Epsilon antibodyAnti-Ckie antibodyAnti-CSNK1E antibody |
Information sourced from Uniprot.org